邢唷> JLI欹q` 餜AbjbjqPqP8D::    8J L 4  $ch<] < z  & T楌C; FvB0,O"O&O&   << $   2nd semester of 2010^2011 Final examination for Immunology A CourseMedical Immunology Course Number MED130209.01 Department Immunology Student name Number Total scores Concepts123456789101112Subtotal scoresscoreQuestions123456Subtotal scoresscore Concepts (4 points each) 1. IL-2 IL-2 is produced mainly by CD4 T lymphocytes. IL-2 is a growth factor for antigen-stimulated T lymphocytes and is responsible for T cell clonal expansion after antigen recognition. 2. TAA tumor-associated antigen are normal proteins that are produced at low levels in normal cells and over expressed in tumor cells. 3. hypersensitivity Disorders are caused by immune response; `!a!b! type of hypersensitivity are mediated by antibodies, while c! type of hypersensitivity is T lymphocyte mediated 4. PAMPs pathogen-associated molecular patterns; The innate immune system recognizes molecular structures that are characteristic of microbial pathogens but not mammalian cells.; Examples of PAMPs are nucleic acids, flagellin, Cell wall lipids and carbohydrates. 5. ((T cell a minor subset of T lymphocytes with TCR composed of (( chains; limited specifities for peptide and nonpeptide antigens; not MHC restricted cytotoxic function in innate immunity 6. TCR-CD3 complex T cell receptor (TCR) is the antigen receptor of T lymphocytes noncovalently associated with the CD3 proteins; When the TCR recognizes antigens, CD3 transduce the signals that lead to T cell activation. 7. HLA class II molecule human MHC (major histocompatibility complex); HLA-DP0DQ0DR; expressed only on dendritic cells, B lymphocytes, macrophages; presenting exogenous antigens to CD4 T cells 8. CD40 mainly expressed on APCs; Interaction between CD40(receptor) and its ligand (CD40L on activated T cells) in T-dependent B cell activation provides B cells a costimulatory signal (2nd activation signal) and promotes clonal expansion and differentiation; activates macrophage for enhanced killing of phagocytosed bacteria 9. Ig class switch In response to CD40 engagement and cytokines, some of the progeny of activated IgM- and IgD-expressing B cells undergo the process of heavy chain isoptype (class) switching, leading to the production of antibodies with heavy chains of different classes, such as (, (, and (, but the V regions and the specificity do not. 10. autoimmune disease Failure of self-tolerance results in immune reactions against self antigens棗autoimmunity, and the diseases they cause are called autoimmune diseases. 11. opsonization Phagocytes express the receptors for the Fc portion of IgG antibodies and complement proteins; Microbes coated with antibodies and complement promote phagocytosis of phagocytes; 12. GVHR Graft versus host reaction; Caused by the reaction of grafted mature T cells in the marrow inoculum with alloantigens of the host Questions 1. Describe the  HYPERLINK "http://www.brown.edu/Courses/Bio_160/Projects1999/cancer/imevstca.html" \t "_blank" immune evasion strategies of cancer. (8 points) Intrinsic mechanisms of Immune Evasion by Tumor cells Tumors may lose expression of antigens that elicit immune responses; Tumor antigens may be inaccessible to the immune system; Tumors may fail to induce strong effector T cell responses because most tumor cells do not express costimulators or class II MHC molecules; Tumors may engage molecules that inhibit immune responses; Secreted products of tumor cells may suppress anti-tumor immune responses Extrinsic Cellular Suppression of Anti-Tumor Immunity Tumor-associated macrophages may promote tumor growth and invasiveness by altering the tissue microenviroment and by suppressing T cell responses; Regulatory T cells may suppress T cell responses to tumors; Myeloid-derived suppressor cells (MDSCs) are immature myeloid precursors and suppress anti-tumor innate and T cell responses 2. Describe the phases of T cell response. (8 points) Antigen recognition; Antigen-induced T cell activation; Clonal expansion and differentiation 3. Describe the process of exogenous antigen presented by MHC class II molecule. (8 points) Generation of Vesicular Proteins; Proteolytic digestion of proteins in vesicles; Biosynthesis and transport of class II MHC molecules to endosomes Association of processed peptides with class II MHC molecules in Vesicles; Expression of peptide-class II MHC complexes on the cell surface 4. Function and significance of MHC in control of immune response. (8 points) Antigen presenting molecules; MHC restriction in antigen recognition and effector function of T cells; Selection process in T lymphocyte development in thymus; Self tolerance and autoimmunity; The major determinant of disease susceptibility between individuals 5. The feature of secondary humoral immune response. 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